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US 2014/0274727 A1Published application
Caries genetic predisposition analysis by molecular testing
AssigneeDental Gene ID, LLC
InventorDaniel R. Cohen
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Abstract
Means and methods of predicting future dental problems are disclosed. Molecular tests use biological matter from a patient to obtain information regarding various genes. The tests and methods generate displays and reports regarding genetic risk pertaining to cavities, tooth decay and other disorders.
Claims9
A method for testing a predisposition for caries, the method comprising the steps of:
- a) obtaining a sample of biological material from a patient;
- b) obtaining a sequence of TAS2R38, TAS1R2, and the following single-nucleotide polymorphisms (SNPs):
- rs635808, rs17057381, rs4251631, rs118500320, rs9793739, rs1383934, and rs11099896 from the biological material;
- c) comparing the obtained sequence of TAS2R38 and TAS1R2, and the following SNPs:
- rs635808, rs17057381, rs4251631, rs118500320, rs9793739, rs1383934, rs11099896;
- to that of a non-risk individual;
- and
- d) wherein the patient's obtained sequence of TAS2R38 and TAS1R2 and the following SNPs:
- rs635808, rs17057381, rs4251631, rs118500320, rs9793739, rs1383934, and rs11099896 is different than that of a non-risk individual indicates a predisposition to caries.
6 more elements
A method of testing a genetic predisposition for caries, the method comprising the steps of:
- a) obtaining a sample of saliva from a patient;
- b) sequencing the sample of saliva to obtain sequencing of alleles mapped to TAS2R38 and TAS1R2 and the following SNPs:
- rs635808, rs17057381, rs4251631, rs118500320, rs9793739, rs1383934 and rs11099896;
- c) wherein observed alleles mapped to TAS2R38 indicates a predisposition to caries;
- d) wherein observed alleles mapped to TAS1R2 indicates a predisposition to caries:
- and
- e) wherein observed alleles mapped to one or more of the following SNPs:
- rs635808, rs17057381, rs4251631, rs118500320, rs9793739, rs1383934 or rs11099896, indicates a predisposition to caries.
5 more elements
A method of testing a genetic predisposition for caries, the method comprising the steps of:
- a) obtaining a sample of saliva from a patient;
- b) testing the saliva to confirm the presence of TAS2R38, TAS1R2, or one of the following SNPs:
- rs635808, rs17057381, rs4251631, rs118500320, rs9793739, rs1383934 or rs11099896;
- c) wherein the presence of TAS2R38 indicates a genetic predisposition to caries;
- d) wherein the presence of TAS1R2 indicates a genetic predisposition to caries;
- and
- e) wherein observed alleles mapped to one of the following SNPs:
- rs635808, rs17057381, rs4251631, rs118500320, rs9793739, rs1383934, rs11099896, indicates a predisposition to caries.
5 more elements
Dependencies are inferred from the claim text.