Bone Marrow Concentrator
OwnerSean Kerr, Jay Smith +1inventors
InventorsSean Kerr, Jay Smith, Meredith Hans Moore
Life of this patent
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Abstract
Instrumentation is provided for the separation of a multiple component sample, such as BMA containing lysed red blood cells and a lysing agent, into a desired component, for example a cell pellet containing stem cells, and a remaining component. The application discloses a device that includes a separator configured to separate the desired portion from the remaining portion, a collector that is supported by the separator and configured to collect the desired component of the multiple component sample after the desired component has been separated from the remaining component by the separator, and a housing that at least partially encloses and supports the separator and the collector.
Claims30
A collection tray configured to rotate about an axis of rotation to separate a multiple component sample into a desired component and a remaining component, the collection tray defining a ray line that extends perpendicularly from the axis of rotation, the collection tray comprising:
- a collection body configured to receive the multiple component sample;
- a plurality of lobes supported by the collection body, each of the lobes having two lobe base portions, an apex, and two lobe side walls that each extend between one of the lobe base portions and the apex, wherein each of the lobes defines a straight lobe line that perpendicularly intersects one of the lobe side walls at a point located radially between the respective lobe base portion and the apex, such that the ray line intersects the point so as to define a lobe angle measured between the ray line and the lobe line;
- wherein the lobe angle is greater than a specific angle, such that the arctangent of the specific angle is equal to the effective coefficient of friction of the desired component and the lobe side wall.
A device configured to separate a multiple component sample into a desired component and a remaining component, the device comprising:
- a bowl portion defining an interior configured to receive the multiple component sample, the bowl portion configured to rotate about an axis of rotation;
- and
- a collection tray configured to be supported by the bowl portion so as to rotate about the axis of rotation, the collection tray defining a ray line that extends perpendicularly from the axis of rotation, the collection tray including at least one lobe that has two lobe base portions, an apex, and two lobe side walls that each extend from one of the lobe base portions to the apex, wherein the at least one lobe at least partially defines a basin that is in fluid communication with the interior of the bowl portion such that the multiple component sample is transferable from the interior to the basin during rotation of the bowl portion about the axis of rotation,
- wherein the at least one lobe further defines a lobe line that is different from the ray line, the ray line intersects one of the lobe side walls at a point along the lobe side wall, and the lobe line perpendicularly intersects the point so as to define a lobe angle between the ray line and the lobe line.
A process to process a withdrawn BMA sample, the process including the steps of:
- combining the withdrawn BMA sample and a red blood cell lysing agent so as to form a multiple component sample;
- rotating a device about an axis of rotation, the device containing the multiple component sample, so as to separate the multiple component sample into a desired component and a remaining component;
- and
- collecting at least a portion of the desired component.
Dependencies are inferred from the claim text.