US 2014/0273276 A1 · SYSTEM AND METHOD FOR A MICROFLUIDIC CALORIMETER

Abstract

Systems and methods are disclosed herein for a microfluidic calorimeter apparatus. A microfluidic calorimeter system includes a calorimetry apparatus and a processor in connection with the apparatus. The apparatus includes a microfluidic laminar flow channel connected to two inlets for flowing fluid into the laminar flow channel. Below the laminar flow channel is a plurality of microscale temperature sensors at known positions in the channel. The processor is in connection with the discrete temperature sensors and determines a calorimetry measurement based on local temperatures derived from data output by the microscale temperature sensors and the respective positions of the sensors in the channel.

Claims37

Dependent claims

A method for calorimetry comprising;

providing a calorimetry apparatus comprising:
a microfluidic laminar flow channel;
a first inlet coupled to the laminar flow channel;
a second inlet coupled to the laminar flow channel;
a fluid injector coupled to the first inlet;
and
a plurality of microscale sensors disposed along the microfluidic laminar flow channel;
flowing a first fluid through the first inlet into the microfluidic laminar flow channel;
flowing a second fluid through the second inlet into the microfluidic flow channel;
injecting a first reagent bolus into the first flow channel via the fluid injector, such that the first reagent comes into contact with the second fluid in the microfluidic flow channel;
and
calculating a calorimetry measurement over a plurality of reagent concentrations as the first reagent bolus flows through the microfluidic flow channel.

9 more elements

Dependencies are inferred from the claim text.

System and method for a microfluidic calorimeter

Life of this patent

System and method for a microfluidic calorimeter

Life of this patent

Abstract

Claims37