Back to results
US 2014/0273273 A1Published application
Biomarkers to improve prediction of heart failure risk
OwnerChristie Mitchell Ballantyne, Ron Cornelis Hoogeveen +2inventors
InventorsChristie Mitchell Ballantyne, Ron Cornelis Hoogeveen, Vijay Nambi, Lloyd E. Chambless
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to the field of laboratory diagnostics. Specifically, methods are disclosed for determining a patient's risk of suffering from heart failure (HF) based on the detection of NT-proBNP, troponin T, and/or a natriuretic peptide. Also disclosed are methods for improving both the accuracy and speed of HF risk models by incorporating biomarker data from patient samples.
Claims8
A method for diagnosing heart failure risk in a subject, comprising:
- a. obtaining the subject's simplified model factors;
- b. obtaining the amount of Troponin T (TnT) and NT-pro B-type natriuretic peptide (NT-proBNP) in a biological sample obtained from the subject;
- c. obtaining a simplified model score based on the amount of TnT and NT-proBNP in the biological sample obtained from the subject and the subject's simplified model factors;
- d. obtaining the alignment value of the simplified model score compared to a clinical model score;
- and
- e. providing a diagnosis of heart failure risk if the alignment value exceeds a threshold.
3 more elements
A method for identifying a subject as in need of therapy for heart failure, comprising:
- a. obtaining the subject's simplified model factors;
- b. contacting a portion of a biological sample obtained from the subject with an antibody immunoreactive for Troponin T (TnT);
- c. contacting a portion of the biological sample obtained from the subject with an antibody immunoreactive for a NT-pro B-type natriuretic peptide (NT-proBNP);
- d. determining an amount of TnT and an amount of NT-proBNP in the biological sample obtained from the subject;
- e. determining a simplified model score based on the amount of TnT and NT-proBNP in the biological sample obtained from the subject and the subject's simplified model factors;
- f. comparing the simplified model score to a clinical model score to determine an alignment value;
- and
- g. identifying the subject as in need of therapy for heart failure if the alignment value is above a threshold.
5 more elements
A method for facilitating a therapeutic decision in a subject, comprising:
- a. obtaining the subject's simplified model factors;
- b. contacting a first portion of a biological sample obtained from the subject with a first antibody immunoreactive for Troponin T (TnT) and contacting a second portion of the biological sample obtained from the subject with a second antibody immunoreactive for a NT-pro B-type natriuretic peptide (NT-proBNP);
- c. determining an amount of TnT and an amount of NT-proBNP in the biological sample obtained from the subject;
- d. determining a simplified model score based on the amount of TnT and NT-proBNP in the biological sample obtained from the subject and the subject's simplified model factors;
- and
- e. fitting the simplified model score/curve to a clinical model score;
- wherein a fit above a threshold is indicative of a need for therapy for heart failure risk.
4 more elements
A method of selecting a treatment for a subject with heart failure risk, comprising:
- a. obtaining the subject's simplified model factors;
- b. contacting a portion of a biological sample obtained from the subject with an antibody immunoreactive for Troponin T (TnT);
- c. contacting a portion of the biological sample obtained from the subject with an antibody immunoreactive for a NT-pro B-type natriuretic peptide (NT-proBNP);
- d. determining an amount of TnT and an amount of NT-proBNP in the biological sample obtained from the subject based on said steps of contacting;
- e. calculating a simplified model score based on the amount of TnT and NT-proBNP determined in said step of determining and the subject's simplified model factors;
- f. aligning the simplified model score to a clinical model score;
- and
- g. selecting a treatment for heart failure when the simplified model score significantly aligns to the clinical model score.
5 more elements
A model for predicting risk of heart failure in a subject, comprising:
- a. simplified model factors obtained from the subject;
- b. an amount of Troponin T (TnT) in a biological sample obtained from the subject;
- and
- c. an amount of NT-pro B-type natriuretic peptide (NT-proBNP) in a biological sample obtained from the subject;
- wherein the simplified model factors, amount of TnT, and amount of NT-proBNP are operatively combined/calculated to predict risk of heart failure in a subject.
2 more elements
A system/device/assay adapted for facilitating a therapeutic decision in a subject, comprising:
- a. means for contacting a first portion of a biological sample from the subject with a first antibody immunoreactive for Troponin T (TnT);
- b. means for contacting a second portion of the biological sample obtained from the subject with a second antibody immunoreactive for NT-pro B-type natriuretic peptide (NT-proBNP);
- c. a computing device having a processor;
- and
- d. a non-transient machine readable media including a plurality of instructions executable by the processor, the instructions, when executed, determine a simplified model score based on the amount of TnT and NT-proBNP in the biological sample obtained from the subject and the subject's simplified model factors, and provide an output indicating a need for therapy for heart failure risk in the subject if the simplified model score significantly aligns to a clinical model score.
2 more elements
A method of predicting a clinical heart failure risk score in a subject, comprising:
- a. obtaining the subject's simplified model factors;
- b. obtaining the amount of Troponin T (TnT) and NT-pro B-type natriuretic peptide (NT-proBNP) in a biological sample obtained from the subject;
- c. obtaining a simplified model score based on the amount of TnT and NT-proBNP in the biological sample obtained from the subject and the subject's simplified model factors;
- d. obtaining the alignment value of the simplified model score compared to a clinical model score;
- and
- e. predicting a clinical heart failure risk score if the alignment value exceeds a threshold.
3 more elements
A method of improving the prediction accuracy of a clinical heart failure risk score for a subject, comprising:
- a. obtaining the clinical heart failure risk score for the subject;
- b. obtaining an amount of Troponin T (TnT) and an amount of NT-pro B-type natriuretic peptide (NT-proBNP) in a biological sample obtained from the subject;
- and
- c. combining the amount of TnT and NT-proBNP with the clinical heart failure risk score to improve the prediction accuracy of the clinical heart failure risk score for the subject.
1 more element
Dependencies are inferred from the claim text.