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US 2014/0273250 A1Published application
Methods for the selective detection of alkyne-presenting molecules and related compositions and systems
AssigneeLawrence Livermore National Security, LLC
InventorsCarlos A. VALDEZ, Audrey M. WILLIAMS
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Abstract
Provided herein are methods for selectively detecting an alkyne-presenting molecule in a sample and related detection reagents, compositions, methods and systems.
Claims17
A method for selectively detecting an alkyne-presenting molecule in an unprepared sample, the method comprising:
- contacting the detection reagent with the unprepared sample for a time and under a condition so as to bind the one or more alkyne-presenting molecules possibly present in the sample to the detection reagent;
- wherein the detection reagent comprises an organic or organometallic label moiety presenting an azide or sulfonyl azide group and wherein binding of the azide or sulfonyl azide group to the alkyne-presenting molecules results in emission of a signal from the organic or organometallic label moiety.
A detection reagent comprising:
- one or more label organic or organometallic moieties, the label organic or organometallic moieties each presenting an azide or sulfonyl azide group;
- wherein the label organic or organometallic moieties are adapted to produce a signal when the detection reagent is bound to one or more alkyne-comprising molecules.
Dependencies are inferred from the claim text.