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US 2014/0273246 A1Published application
Rare earth spatial/spectral microparticle barcodes for labeling of objects and tissues
AssigneeMassachusetts Institute of Technology
InventorsPaul Bisso, Albert Swiston, Jiseok Lee, Patrick S. Doyle
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Abstract
Polymer microparticles spatially and spectrally encoded using upconversion nanocrystals (UCN) are described for labeling of articles and tissues. UCN having spectrally distinguishable emission spectra are disposed in different portions of an encoding region of each microparticle.
Claims31
A microparticle for labeling, the microparticle comprising:
- a body comprising a polymer material and including an encoded region;
- a first plurality of upconversion nanocrystals disposed in a first portion of the encoded region, the first plurality of upconversion nanocrystals having a first spectral signature;
- and
- a second plurality of upconversion nanocrystals disposed in a second portion of the encoded region spatially separated from the first portion of the encoded region, the second plurality of upconversion nanocrystals having a second spectral signature.
1 more element
A method of making a microparticle for labeling, the method comprising:
- providing a first encoded region source material including a polymer and a first plurality of upconversion nanocrystals having a first spectral signature;
- providing a second encoded region source material including a polymer and a second plurality of upconversion nanocrystals having a second spectral signature different from the first spectral signature;
- forming a contiguous microparticle by cross-linking with the first encoded region source material forming a first portion of an encoded region of the microparticle, and with the second encoded region source material forming a second portion of the encoded region.
Dependencies are inferred from the claim text.