GSK3 Ligands and Polynucleotides Encoding GSK3 Ligands
AssigneeIntrexon Corporation
InventorsThomas D. REED, Amy H. ATZEL
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Abstract
The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands and polyligands that modulate GSK3 activity. The ligands and polyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands and polyligands to a cellular localization signal, epitope tag and/or a reporter. The invention also includes polynucleotides encoding the ligands and polyligands.
Claims27
An isolated polynucleotide encoding a polypeptide that is at least 90% identical to SEQ ID NO:7 or SEQ ID NO:10, wherein the polypeptide is not glycogen synthase kinase-3, and wherein the polypeptide inhibits kinase activity of glycogen synthase kinase-3.
(canceled)
An isolated polynucleotide encoding a polypeptide comprising two or more polypeptides selected from SEQ ID NOS:
- 46-122, wherein Xaa is any amino acid.
-9. (canceled)
(canceled)
(canceled)
(canceled)
Dependencies are inferred from the claim text.