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US 2014/0273192 A1Published application
System for high throughput sperm sorting
AssigneeInguran, LLC
InventorsJohnathan Charles Sharpe, Nemanya Sedoglavich, Kris Buchanan, Blair Morad, Donald Francis Perrault, JR., Erin Koksal
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Abstract
This disclosure relates to a system for sorting sperm cells in a microfluidic chip. In particular, various features are incorporated into the system for aligning and orienting sperm in flow channels, as well as, for determining sperm orientation and measuring relative DNA content for analysis and/or sorting.
Claims103
A sperm sorting system comprising:
- a sample source;
- a substrate;
- at least one flow channel formed in the substrate, the flow channel having an inlet in fluid communication with the sample source, the flow channel further comprising an inspection region, a first outlet, and second outlet;
- at least one diverting mechanism in communication with each of the at least one flow channels to selectively divert sperm in the at least one flow channel away from the first outlet;
- an electromagnetic radiation source for illuminating sperm at the inspection region;
- a detector aligned to measure sperm characteristics in the inspection region of the at least one flow channel;
- an analyzer in communication with the detector to determine sperm characteristics;
- a controller in communication with the analyzer for selectively activating the diverting mechanism based on measured sperm characteristics;
- and
- a collection vessel in communication with the second outlet.
7 more elements
Dependencies are inferred from the claim text.