Methods and compositions involving fibrillizing polypeptides for nanofibers
AssigneeThe University of Chicago
InventorsJOEL COLLIER, GREGORY HUDALLA
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Abstract
Embodiments of the invention are directed to fibrillar adjuvants. For example, epitopes assembled by a synthetic peptide domain into nanofibers comprising a β-fibrillization peptide may elicit high antibody titers in the absence of any adjuvant. In certain embodiments, multiple different antigens may be integrated into polypeptide nanofibers, providing biomaterials with modular and precise composition of bioactive proteins.
Claims30
A nanofiber complex composition, wherein the composition comprises a β-sheet nanofiber structure comprising
- a) a plurality of non-β-sheet peptide tags, wherein a non-β-sheet peptide tag is attached to a compound;
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- b) a plurality of β-sheet peptides.
The composition of 1, wherein the non-β-sheet peptides tags are α-helical peptides.
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Dependencies are inferred from the claim text.