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US 2014/0273095 A1Published application
Serum-Free Cell Culture Medium
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsShadia Abike OSHODI, Amy S. JOHNSON, Shawn M. LAWRENCE
Life of this patent
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Abstract
The specification describes an improved serum-free animal cell culture medium, which can used for the production of a protein of interest. Ornithine, or a combination of ornithine and putrescine can be added to serum-free media or chemically defined media to improve viable cell density, to reduce cell doubling time, and to increase the production of a protein of interest.
Claims48
A cell culture medium, which is serum-free, comprising ≧0.09 mM±0.014 mM ornithine.
Dependencies are inferred from the claim text.