Biomarkers for multiple sclerosis
AssigneeUniversiteit Hasselt
InventorsVeerle Somers, Pieter Stinissen
Life of this patent
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Abstract
Described is the diagnosis of neurological disorders, more specifically, the diagnosis of multiple sclerosis. A biomarker panel is provided that can be used to detect if a subject has multiple sclerosis. Also described are methods of identification of such biomarkers.
Claims15
A method of detecting at least one specific antibody to Sperm-Associated Antigen 16's (SPAG16's) presence and/or quantity, the method comprising:
- contacting a body fluid from a mammal with SPAG16 protein and/or a peptide fragment of at least 5 consecutive amino acids of SPAG16, and
- detecting the presence or measuring the quantity of specific antibodies bound to SPAG16 protein and/or the peptide fragment.
A method of diagnosing multiple sclerosis in a mammal, the method comprising:
- contacting a body fluid of the mammal with Sperm-Associated Antigen 16 (SPAG16) protein or a peptide fragment of at least 5 consecutive amino acids of SPAG16 protein, and
- detecting the presence or measuring the quantity of at least one specific antibody bound to SPAG16 protein or the peptide fragment,
- wherein the presence of and/or increased quantity of bound antibody as compared to a negative control indicates multiple sclerosis in the mammal.
A method for evaluating the prognosis and/or disease severity of multiple sclerosis in a subject suffering therefrom, the method comprising:
- contacting a body fluid of the subject with Sperm-Associated Antigen 16 (SPAG16) protein and/or a peptide fragment of at least 5 consecutive amino acids of SPAG16 protein, and
- detecting the presence or measuring the quantity of at least one specific antibody bound to SPAG16 protein and/or the peptide fragment,
- wherein the decreased or increased concentration of the at least one specific antibody indicates the prognosis of multiple sclerosis in the subject.
A method for selecting a patient for a specific therapeutic treatment of multiple sclerosis or evaluating the therapeutic treatment of multiple sclerosis in a subject suffering therefrom, the method comprising:
- contacting a body fluid of the subject with Sperm-Associated Antigen 16 (SPAG16) protein or a peptide fragment of at least 5 consecutive amino acids of SPAG16 protein, and
- detecting the presence or measuring the quantity of the specific antibodies bound to SPAG16 protein or the peptide fragment,
- wherein the presence or quantity of the antibody leads to an election of a specific therapeutic treatment of multiple sclerosis in the subject.
A diagnostic kit comprising:
- Sperm-Associated Antigen 16 (SPAG16) protein or a peptide fragment of at least 5 consecutive amino acids of SPAG16 protein,
- reagents for making a medium appropriate for an immunological reaction to occur, and
- reagents that detect an antigen/antibody complex that has been produced by the immunological reaction.
SPAG16 or a peptide fragment of at least 5 consecutive amino acids of SPAG16 protein bound to a solid support.
A peptide comprising SEQ ID NO:8 bound to a solid support or label.
Dependencies are inferred from the claim text.