System and method for determining risk of pre-eclampsia based on biochemical marker analysis
AssigneeWallac Oy
InventorsPertti Hurskainen, Teemu Korpimäki, Heikki Kouru, Mikko Sairanen
Life of this patent
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Abstract
A method for predicting risk of pre-eclampsia in a pregnant individual includes measuring one or more biochemical markers including an RBP4 biochemical marker in a blood sample obtained from the pregnant individual to determine one or more biomarker levels including an RBP4 biomarker level, identifying, for each of the one or more measured biochemical markers, a difference between the measured biomarker level and a corresponding predetermined control level, and, responsive to the identifying, determining a prediction corresponding to a relative risk of the pregnant individual having or developing pre-eclampsia.
Claims35
A method for predicting risk of pre-eclampsia in a pregnant individual, the method comprising:
- measuring one or more biochemical markers including an RBP4 biochemical marker in a blood sample obtained from the pregnant individual to determine one or more biomarker levels including an RBP4 biomarker level;
- identifying, by a processor of a computing device, for each of the one or more measured biochemical markers, a difference between the measured biomarker level and a corresponding predetermined control level;
- and
- responsive to the identifying, determining, by the processor, a prediction corresponding to a relative risk of the pregnant individual having or developing pre-eclampsia.
(canceled)
(canceled)
A system for predicting risk of pre-eclampsia in a pregnant individual comprising:
- an in vitro diagnostics kit for testing a blood sample obtained from the pregnant individual for two or more biochemical markers including a retinol binding protein 4 (RBP4) biochemical marker and a placental growth factor (PlGF) biochemical marker;
- and
- a non-transitory computer-readable medium having instructions stored thereon, wherein the instructions, when executed by a processor, cause the processor to:
- retrieve two or more biomarker levels from the blood sample, wherein each biomarker level of the two or more biomarker levels corresponds to a biochemical marker tested for using the in vitro diagnostics kit, and wherein the retrieved two or more biomarker levels comprises an RBP4 biomarker level and a PlGF biochemical marker level, and
- calculate a risk assessment score corresponding to a relative risk of the pregnant individual having or developing pre-eclampsia, wherein the risk assessment score is based at least in part upon the RBP4 biomarker level and the PlGF biomarker level.
(canceled)
A method for predicting risk of pre-eclampsia in a pregnant individual, the method comprising:
- measuring one or more biochemical markers in a blood sample obtained from the pregnant individual to determine one or more biomarker levels, wherein
- a first biomarker of the one or more biochemical markers comprises RBP4, and a first biomarker level comprises an RBP4 biomarker level;
- and
- calculating, by a processor of a computing device, a risk assessment score corresponding to a relative risk of the pregnant individual having or developing pre-eclampsia, wherein the risk assessment score is based at least in part upon the RBP4 biomarker level.
35-41. (canceled)
Dependencies are inferred from the claim text.