System for rapidly detecting infectious agents using a hybridoma-based biosensor

6) A system for rapidly detecting infectious agents in biological samples, comprising:

• (a) at least one sample to be tested for at least one specific infectious agent;
• and
• (b) at least one biosensor, wherein the biosensor is operative to detect a specific infectious agent in the sample to be tested;
• wherein the biosensor emits a detectable signal when it reacts with the specific infectious agent;
• wherein the biosensor is a hybridoma cell that naturally expresses an endogenous anti-target antigen specific IgM;
• and wherein the hybridoma cell has been converted to a B cell receptor biosensor by introducing a detectable reporter gene into the cell.

17) A system for rapidly detecting infectious agents in biological samples, comprising:

• (a) at least one sample to be tested for at least one specific infectious agent;
• and
• (b) at least one biosensor, wherein the biosensor is operative to detect a specific infectious agent in the sample to be tested;
• wherein the biosensor emits a detectable signal when it reacts with the specific infectious agent;
• wherein the biosensor is a hybridoma cell that naturally expresses an endogenous anti-target antigen specific IgM;
• wherein the hybridoma cell has been converted to a B cell receptor biosensor by introducing a detectable reporter gene into the cell;
• and wherein the detectable reporter gene is an aequorin reporter gene.