Device and method for the detection and diagnosis of aggressive and metastatic cancer and cancer stem cells employing podocalyxin and tra biomarkers
OwnerWilliam Michael Schopperleinventor
Life of this patent
Estimating the term…
Abstract
The invention relates to devices and methods to detect podocalyxin and TRA molecules in a biological sample obtained from a patient and therefore, to detect the presence of podocalyxin-expressing and TRA-expressing cancer stem cells in a patient. The invention further relates to devices and methods to determine a diagnosis of aggressive or metastatic cancer by employing podocalyxin and TRA as biomarkers.
Claims15
A method of detecting the presence of podocalyxin and/or TRA molecules in a first patient, comprising:
- obtaining a first biological sample from the first patient, the first sample selected from the group consisting of a blood-derived specimen, a seminal fluid specimen, a urine specimen, and combinations thereof;
- testing the first biological sample for the presence of podocalyxin and/or TRA molecules;
- and
- determining the presence or absence of podocalyxin and/or TRA molecules in the first biological sample.
A method of detecting and diagnosing aggressive cancer stem cells in a patient, comprising:
- obtaining a biological sample from the patient, the biological sample selected from the group consisting of a blood-derived specimen, urine specimen and combinations thereof;
- analyzing the biological sample for a presence of podocalyxin and/or TRA molecules selected from the group consisting of anti-podocalyxin, TRA-1-60, TRA-1-81 and mixtures thereof;
- determining the presence or an absence of the podocalyxin and/or TRA molecules in the biological sample;
- providing a diagnosis of the presence of aggressive cancer stem cells in the patient based on the presence of the podocalyxin and/or TRA molecules in the biological sample;
- and
- providing a diagnosis of the absence of aggressive cancer stem cells in the patient based on the absence of the podocalyxin and/or TRA molecules in the biological sample.
A device for detecting and diagnosing aggressive cancer stem cells in a patient;
- the device comprising:
- a tool for obtaining a biological sample from the patient, the biological sample selected from the group consisting of a blood-derived specimen, a seminal fluid specimen, a urine specimen and combinations thereof;
- a detector means for determining the presence or absence of podocalyxin and/or TRA molecules selected from the group consisting of anti-podocalyxin, TRA-1-60, TRA-1-81 and mixtures thereof;
- and
- an indicator means to display the presence of the podocalyxin and/or TRA molecules in the biological sample.
Dependencies are inferred from the claim text.