Methods for analyzing blood to detect diseases associated with abnormal protein aggregation
AssigneeAmira Medical Technologies Inc.
InventorsPeter STYS, Shigeki TSUTSUI
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Abstract
A method of detecting a disease associated with abnormal protein aggregation in a subject is provided, the method comprising (a) contacting leukocytes from the subject with a probe that binds to pathogenic protein aggregates, and (b) detecting the probe bound to the pathogenic protein aggregates, wherein the presence of pathogenic protein aggregates in the leukocytes is indicative that the subject has a disease associated with abnormal protein aggregation. In one embodiment, the disease is Alzheimer's disease or mild cognitive impairment.
Claims30
A method of detecting a disease associated with abnormal protein aggregation in a subject, comprising (a) contacting leukocytes from the subject with a probe that binds to pathogenic protein aggregates, and (b) detecting the probe bound to the pathogenic protein aggregates, wherein the presence of pathogenic protein aggregates in the leukocytes is indicative that the subject has a disease associated with abnormal protein aggregation.
A method for evaluating leukocytes derived from a subject who may have or has a disease associated with abnormal protein aggregation comprising:
- a) obtaining a test blood sample from the subject,
- b) isolating leukocytes from the test blood sample,
- c) contacting the leukocytes with a probe that binds to pathogenic protein aggregates in the leukocytes, and
- d) detecting the probe bound to the pathogenic protein aggregates,
- wherein the presence of pathogenic protein aggregates in the leukocytes is indicative that the subject has a disease associated with abnormal protein aggregation.
A kit for analyzing leukocytes to detect a disease associated with abnormal protein aggregation comprising:
- a) a probe that detects the presence of pathogenic protein aggregates in the leukocytes and
- b) instructions for use.
Dependencies are inferred from the claim text.