Diagnostic microrna profiling in cutaneous t-cell lymphoma (ctcl)
AssigneesLeo Pharma A/S, Copenhagen University, Rigshospitalet, Gentofte Hospital
InventorsUlrik Ralfkiaer, Peter Hagedorn, Charlotte Busch Ahler, Carsten Geisler, Anders Woetmann, Lone Skov, Niels Feentved Odum, Elisabeth Ralfkiaer
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Abstract
The present invention relates to the field of cancer-diagnostics. In particular the invention relates to a microRNA expression signature that allows discriminating skin samples of cutaneous T-cell lymphomas (CTCL) from non-malignant (inflammantory) skin samples by use of quantitative polymerase chain reaction performed on reverse transcribed miRNA. miR-155, miR-326, miR-663b, miR-203 and miR-205 are shown to be differentially expressed.
Claims20
A method for classifying a test skin cell sample from an individual with an inflammatory skin disease as cutaneous lymphomas comprising:
- detecting microRNA expression levels at least of one of miR-155 and miR-326, and at least of one of miR-203 and miR-205,
- calculating a clinical score (S) of the test cell sample based on a dataset comprising the expression levels of said microRNAs, and
- classifying the test cell sample as cutaneous lymphomas or not based on the value of the clinical score.
Dependencies are inferred from the claim text.