Methods of screening for binding interaction using sets of microparticles and unique probes
AssigneeOne Lambda
InventorsJar-How Lee, Terrence Chen, Thoa Nong
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Abstract
The present invention relates to methods for screening for binding interactions using multiple sets of microparticles, wherein said set has the same identifiable characteristic and wherein one of more sets comprise subsets of microparticles and said subset presents at least one unique probe that acts as a binding partner for a target molecule in a biological sample. In particular, the invention provides for methods of detecting tissue-typing antigens in donor tissue or recipient tissue using these multiple sets of microparticles.
Claims10
1-42. (canceled)
A kit for conducting a method of measuring a binding interaction comprising:
- multiple sets of uniquely identifiable microparticles having the same unique identifiable characteristic, wherein said set comprises subsets of microparticles said subset presenting at least one unique probe that binds to a target molecule within a biological sample.
A kit for conducting a method of DNA-based tissue typing comprising:
- multiple sets of uniquely identifiable microparticles having the same unique identifiable characteristic, wherein said set comprises subsets of microparticles said subset presenting at least one unique sequence specific oligonucleotide (SSO) selected to hybridize with a tissue-typing antigen allele.
Dependencies are inferred from the claim text.