Methods and kits for diagnosing, prognosticating risk/outcome, and/or treating breast cancer
AssigneeQueen's University at Kingston
InventorsChristopher Robert Mueller, Kirsten A. Nesset
Life of this patent
Estimating the term…
Abstract
Methods and kits for diagnosing, prognosticating risk of, and selecting and/or administering a therapy for breast cancer based upon detection of methylated glucocorticoid receptor gene or measurement of glucocorticoid receptor and BRCA1 gene expression levels are provided.
Claims28
A method for diagnosing breast cancer in a subject, said method comprising detecting a methylated glucocorticoid receptor (GR) promoter in the subject wherein detection of the methylated glucocorticoid receptor promoter is indicative of breast cancer in the subject.
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A method for diagnosing breast cancer in a subject, said method comprising:
- measuring a level of glucocorticoid receptor gene expression in the subject;
- measuring a level of BRCA1 gene expression in the subject, and
- comparing measured levels of glucocorticoid receptor and BRCA1 gene expression in the subject with respective standard levels of glucocorticoid receptor and BRCA1 gene expression;
- wherein a low level of glucocorticoid receptor gene expression as compared to the standard level and an abnormal level of BRCA1 gene expression in the subject as compared to the standard level is indicative of breast cancer.
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A method for prognosticating outcome of a subject diagnosed with breast cancer, said method comprising detecting a methylated glucocorticoid receptor (GR) promoter in the subject wherein detection of the methylated glucocorticoid receptor promoter is indicative of outcome for the subject.
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A kit for diagnosing breast cancer and/or prognosticating outcome of a subject with breast cancer, said kit comprising means for measuring a methylated glucocorticoid receptor (GR) promoter in a sample from a subject.
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Dependencies are inferred from the claim text.