Administration And Monitoring Of Nitric Oxide In Ex Vivo Fluids
AssigneeINO Therapeutics LLC
InventorsJim Potenziano, Douglas R. Hansell, Jeff Griebel, Eddie Costa, Lisa Cooper
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Abstract
Described are systems and methods for monitoring administration of nitric oxide (NO) to ex vivo fluids. Examples of such fluids include blood in extracorporeal membrane oxygenation (ECMO) circuits or perfusion fluids used for preserving ex vivo organs prior to transplanting in a recipient. The systems and methods described herein provide for administering nitric oxide to the fluid, monitoring nitric oxide or a nitric oxide marker in the fluid, and adjusting the nitric oxide administration.
Claims27
A method of monitoring nitric oxide administration comprising:
- administering nitric oxide to an ex vivo fluid comprising red blood cells by contacting the ex vivo fluid with a gas comprising a nitric oxide concentration in the range from 1 ppm to 300 ppm;
- monitoring nitric oxide or a nitric oxide marker in the ex vivo fluid after administrating nitric oxide to the ex vivo fluid;
- adjusting the nitric oxide administration based on the monitoring of the nitric oxide or nitric oxide marker;
- and
- contacting cells with the ex vivo fluid after administering nitric oxide to the ex vivo fluid.
A method of monitoring nitric oxide administration during extracorporeal membrane oxygenation (ECMO) comprising:
- administering nitric oxide to ex vivo blood in an ECMO circuit by contacting the ex vivo blood with a gas comprising a nitric oxide concentration in the range from 1 ppm to 50 ppm;
- monitoring one or more of (1) a pressure drop in the ECMO circuit to determine if the pressure drop is above a pressure drop threshold or (2) nitric oxide or a nitric oxide marker in the ex vivo blood to determine if the nitric oxide or nitric oxide marker is below or above a nitric oxide threshold;
- and
- adjusting the nitric oxide administration based on one or more of the monitoring of the pressure drop or the monitoring of the nitric oxide or nitric oxide marker, wherein the nitric oxide administration is increased if the pressure drop is above the pressure drop threshold and the nitric oxide administration is decreased if the nitric oxide or nitric oxide marker is above the nitric oxide threshold.
A method of monitoring nitric oxide administration to an ex vivo fluid for biological material preservation comprising:
- administering nitric oxide to an oxygenated ex vivo fluid comprising red blood cells by contacting the ex vivo fluid with a gas comprising a nitric oxide concentration in the range from 20 ppm to 200 ppm;
- monitoring nitric oxide or a nitric oxide marker in the ex vivo fluid;
- adjusting the nitric oxide administration based on the monitoring of the nitric oxide or nitric oxide marker.
A system for delivering and monitoring nitric oxide comprising:
- a nitric oxide delivery device for administering nitric oxide to an ex vivo fluid by contacting the ex vivo fluid with a gas comprising a nitric oxide concentration in the range from 1 ppm to 300 ppm;
- and
- a monitoring device for monitoring nitric oxide or a nitric oxide marker in the ex vivo fluid, wherein the monitoring device is in communication with the nitric oxide delivery device and the nitric oxide delivery device adjusts the nitric oxide administration based on the monitoring of the nitric oxide or nitric oxide marker.
Dependencies are inferred from the claim text.