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US 2014/0272101 A1Published application
Microarray for delivery of therapeutic agent, methods of use, and methods of making
AssigneeCorium International, Inc.
InventorsGuohua Chen, Zhongli Ding, Esi Ghartey-Tagoe, Ashutosh Shastry, Robert Wade Worsham, Parminder Singh
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Abstract
Devices and methods for using and manufacturing microstructure arrays are described.
Claims25
A method of making an array of microstructures comprising:
- (a) dissolving or suspending at least one therapeutic agent in a first solvent to form a therapeutic agent solution or suspension;
- (b) dissolving at least one polymer in a second solvent to form a polymer solution;
- (c) mixing the therapeutic agent solution or suspension and the polymer solution or suspension to form a polymer matrix solution or suspension;
- (d) dispensing the polymer matrix solution or suspension on a mold having an array of microstructure cavities;
- (e) filling the microstructure cavities in the mold;
- (f) removing excess solution or suspension polymer matrix on the mold surface;
- (g) drying the solution or suspension at a temperature of about 5-50° C. in a chamber having a partial pressure of water of about 0.01 mTorr to about 203 Torr or a relative humidity of about 10-95%;
- (h) drying the solution or suspension at about 5-50° C. for about 30 minutes to form an array of microstructures;
- and
- (i) drying the microstructures under vacuum at about 5-50° C.
7 more elements
The method of any previous claim, further comprising:
- dispensing a basement or backing layer on the mold surface;
- and
- drying the basement or backing layer.
Dependencies are inferred from the claim text.