Low-buffer nutritional compositions and uses thereof
AssigneeMead Johnson Nutrition Company
InventorsAnja Wittke, Dattatreya Banavara
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AssigneeMead Johnson Nutrition Company
InventorsAnja Wittke, Dattatreya Banavara
Estimating the term…
The present disclosure is directed to methods for supporting resistance to bacterial growth in the gastrointestinal tract of a subject, particularly in that of a human infant. In certain embodiments, the method comprises administering to a subject a nutritional composition that has a low buffer strength, wherein administration of said nutritional composition decreases the bacterial counts of bacteria selected from the group consisting of Enteropathogenic E. coli (EPEC), Enteroaggregative E. coli (EAEC), Cronobacter sakazakii, Salmonella enterica, and combinations thereof in the subject's gastrointestinal tract. This disclosure further relates to the manufacture and use of low-buffer nutritional compositions in methods for modulating gastric acidity and/or in methods for enhancing the rate of gastric emptying in a subject, each method comprising a step of administering at least one of said low-buffer nutritional compositions to the subject.
A method for supporting resistance to growth of bacteria in the gastrointestinal tract of a subject, wherein the bacteria is selected from the group consisting of Enteropathogenic E. coli (EPEC), Enteroaggregative E. coli (EAEC), Cronobacter sakazakii, Salmonella enterica, and combinations thereof, the method comprising the step of administering to the subject a nutritional composition having a buffer strength of from about 9 to about 22, wherein the nutritional composition comprises at least one salt having a pKa lower than about 4.
A method for modulating gastric acidity in a subject, the method comprising the step of administering to the subject a nutritional composition having a buffer strength of from about 9 to about 22, wherein the nutritional composition comprises at least one salt having a pKa lower than about 4 and a protein component having a whey to casein ratio of from about 60:40 to about 80:20.
A method of reducing the buffer strength of an infant formula to a level of about 9 to about 22, the method comprising the step of adding a protein component having a whey:casein ratio of from about 60:40 to about 80:20 and at least one salt having a pKa lower than about 4 to the infant formula.
Dependencies are inferred from the claim text.