US 2014/0271931 A1 · Anti-Acne Topical Films

Abstract

Topical formulations containing one or more pharmaceutically acceptable bioadhesive film-forming agent, one or more anti-acne agent, and an aqueous solvent in the form of a solution or suspension are described herein. The formulation may further contain one or more excipients, including evaporation suppressants, humectants, or plasticizers. When the formulation is contacted with the skin of a patient, the solvent evaporates and forms a thin, transparent, and solid bioadhesive film. The bioadhesive film adheres to the skin surface for a prolonged period of time and the anti-acne agent is released into the skin over a prolonged period of time. Typically, the bioadhesive film adheres to the skin for at least 60 minutes following administration of the formulation, preferably for at least 8 hours following administration, more preferably up to 24 hours following administration. The prolonged retention of the anti-acne agent at the site increases the amount of uptake into the skin.

Claims22

Dependent claims

A formulation for treating acne comprising:

one or more pharmaceutically acceptable bioadhesive film-forming agents, one or more anti-acne agents selected from the group consisting of picolinic acid, picolinic acid analogs, and picolinic acid derivatives, and an aqueous solvent,
wherein the film-forming agent is present in an amount from 1-99% weight/volume of the formulation,
wherein the anti-acne agent is present in an amount from 1-99% weight/volume of the formulation;
wherein the formulation, upon application to a skin surface, forms a transparent, solid film after evaporation of the solvent;
and
wherein the film adheres to the skin over a period of time greater than about 1 hour.

3 more elements

Dependencies are inferred from the claim text.

Anti-Acne Topical Films

Life of this patent

Anti-Acne Topical Films

Life of this patent

Abstract

Claims22