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AssigneePeroxyium, Inc., Delaware C Corp.
InventorsJames Leiter, Susan Gillmor, Aleksandar Jeremic, Ekaterina Vert-Wong, Gregg Fairbrothers
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The present invention provides methods and liposomal compositions useful in therapeutics, and diagnosis, prognosis, testing, screening, treatment and/or prevention of various disease conditions. The present invention provides imaging methods for various conditions. The present invention is a multi-layered drug delivery pathway, inclusive of nanoparticle liposomal formulations and mechanisms of localized action via unzipping upon delivery to the affected tissue site. The nano-encapsulation methodology allows maximization of a potent antioxidant's biocompatibility, increased target cell penetration and uptake, reduced off-target effects and retention of high anti-oxidative activity for promising therapeutic potential.
A multi-layered encapsulated cerium oxide nanoparticle (“CeNP”) comprising a cerium oxide nanoparticle and a ligand shell, wherein the CeNP can optionally comprise a hydrocarbon addition, an electron shuttling system, a lipid shell, a targeting molecule attachment, or combinations thereof.
A method of controlling and directing CeNP action against reactive oxygen species, the method comprising:
A method for limiting interactions of a CeNP with blood and tissue in the body, the method comprising:
Dependencies are inferred from the claim text.