Tamper resistant pharmaceutical formulations
AssigneePurdue Pharma L.P.
InventorsRama ABU SHMEIS, Sheetal Muley, Zhixin Zong
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Abstract
Disclosed in certain embodiments is a solid oral dosage form comprising a plurality of particles, each particle comprising (i) a core comprising an active agent susceptible to abuse and an internal adhesion promoter, wherein the cores are (i) dispersed in a matrix comprising a controlled release material or (ii) coated with a controlled release material. The dosage form can also include an alcohol resistant material.
Claims32
A solid oral dosage form comprising a plurality of particles, each particle comprising a core comprising an active agent susceptible to abuse and an internal adhesion promoter, wherein the cores are (i) dispersed in a matrix comprising a controlled release material or (ii) coated with a controlled release material.
10-13. (canceled)
23-77. (canceled)
83-84. (canceled)
A solid oral dosage form comprising a plurality of particles, each particle comprising a core comprising an opioid agonist and a carbomer, wherein the cores are (i) dispersed in a matrix comprising a neutral acrylic polymer and a pore former (ii) coated with a neutral acrylic polymer and a pore former;
- wherein the dosage form further comprises an alkylcellulose.
A process for preparing a solid oral dosage form comprising preparing a plurality of particles by (i) granulating an active agent susceptible to abuse and an internal adhesion promoter to form core granules and (ii) coating or granulating the core granules with a controlled release material to obtain controlled release granules.
87-89. (canceled)
92-96. (canceled)
Dependencies are inferred from the claim text.