Polymorph Compositions, Methods of Making, and Uses Thereof

A process for producing a substantially pure polymorphic form of a bioactive agent encapsulated into microparticles, wherein the process comprises:

• (a) providing a substantially pure crystalline form of the bioactive agent;
• (b) adding the substantially pure crystalline form of the bioactive agent to a polymer solution, thereby creating a mixture of the crystalline form of the bioactive agent and the polymer solution;
• (c) homogenizing the mixture to form a disperse phase;
• (d) mixing the disperse phase with a continuous phase comprising a continuous process medium, thereby forming an emulsion comprising the bioactive agent;
• (e) forming and extracting the microparticles comprising the substantially pure polymorphic form of the bioactive agent;
• and
• (f) drying the microparticles.