Bioerodible Silicon-Based Compositions for Delivery of Therapeutic Agents
AssigneepSivida Inc.
InventorsChristian Barnett, Paul Ashton, Leigh T. Canham
Life of this patent
Estimating the term…
Abstract
The invention comprises a composition comprising a bioerodible porous silicon-based carrier material wherein the carrier material carries at least one large molecule therapeutic agent and at least one amorphous sugar, optionally further comprising a crystallization inhibitor. The composition may be used in vitro or in vivo to deliver the therapeutic agent, preferably in a controlled fashion over an intended period of time such as over multiple days, weeks or months. The composition may be used for treating or preventing conditions of a patient such as chronic diseases.
Claims37
A composition comprising a bioerodible porous silicon-based carrier material wherein the carrier material comprises at least one large molecule therapeutic agent and an amorphous sugar.
3-4. (canceled)
8-10. (canceled)
14-15. (canceled)
(canceled)
35-44. (canceled)
A composition comprising an amorphous sugar and a biomolecule loaded within the pores of a porous silicon-based carrier material, wherein the biomolecule within the carrier material has a half-life at room temperature that is at least twice the half-life of the biomolecule without the carrier material under the same conditions.
A composition comprising an amorphous sugar and a biomolecule loaded within the pores of a porous silicon-based carrier material, wherein the biomolecule within the carrier material has a shelf life at room temperature that is at least twice as long as the shelf life of the biomolecule without the carrier material under the same conditions.
Dependencies are inferred from the claim text.