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US 2014/0271872 A1Published application
Drug delivery system
AssigneePatheon Inc.
InventorsAnh Thu Thi Pham, Akaash Kumari Singh, Stefan Proniuk
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Abstract
Disclosed herein are novel methods of treating diseases, novel dosage forms, and novel methods of modulating the pharmacokinetics of active ingredients.
Claims36
A drug delivery system comprising:
- sodium lauryl sulfate or a polyethylene glycol;
- cellulose;
- lactose;
- polyvinylpyrrolidone;
- a copolymer of polyvinylpyrrolidone and vinyl acetate;
- a silicon dioxide;
- and sodium stearyl fumarate or magnesium stearate.
4 more elements
A drug delivery system comprising at least about 2 to about 15 percent of a glidant and a compound of Formula I:
- or metabolites or pharmaceutically acceptable salts thereof.
A composition comprising a compound of Formula I:
- at least about 2 to about 15% silicon dioxide;
- and
- a pharmaceutically acceptable carrier.
A method of making a drug delivery system, comprising the steps of:
- mixing a compound having Formula I
- sodium lauryl sulphate or polyethylene glycol, and a polyoxyethylene-polyoxypropylene copolymer to form mixture I;
- adding crospovidone or copovidone, lactose, cellulose, and a glidant to mixture I to form mixture II;
- adding sodium stearyl fumarate to mixture II to form mixture III;
- and
- compressing mixture III to form a tablet.
3 more elements
Dependencies are inferred from the claim text.