Therapeutic compositions for bone repair
AssigneesThe Trustees of the University of Pennsylvania, Rutgers, The State University of New Jersey
InventorsKathryn E. Uhrich, Dana Graves
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Abstract
Individuals having diabetes are more prone to fractures, periodontitis, and other bone related issues as compared to healthy individuals. Furthermore, bone healing in diabetic patients is prolonged. The invention provides a method for decreasing bone resorption or increasing bone formation or promoting bone healing in diabetic patients. In particular, a biodegradeable polymer, such as a polyanhydride salicylate is administered at or near a bone defect site, and upon hydrolysis of the polymer will releases biologically active salicylic acid.
Claims19
A method for decreasing bone resorption or increasing bone formation or promoting bone healing at a site in the body of a diabetic mammal comprising, administering at or near the site a biodegradable polymer comprising one or more groups in the polymer backbone, which upon hydrolysis of the polymer will yield a biologically active agent selected from the group consisting of a non-steroidal anti-inflammatory, an antibiotic, an analgesic and an antioxidant.
Dependencies are inferred from the claim text.