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AssigneePharmtak, Inc.
InventorsI-Lan Tung Sue, Jung-Chung Lee
Estimating the term…
Described herein is a pharmaceutical composition comprising lamotrigine as an active ingredient providing a prolonged release characteristic to allow once a day dosage regime. The composition comprises lamotrigine and a swelling agent forming a core or an extended-release composition. The core or an extended-release composition may be coated with a hydrophobic, pH-independent polymer to provide a modified extended-release composition. The formulation may comprise other pharmaceutically acceptable excipients that may act as additional release rate modifier(s), e.g., a pore forming agent in the hydrophobic polymer coat/film. Also described are the processes of preparing such dosage forms and their use.
A modified extended-release composition comprising:
An extended-release composition comprising lamotrigine, and at least one swelling agent.
An extended-release composition comprising about 5% to about 70% by weight of lamotrigine, from about 5% to about 80% Hypromellose 2208 by weight, from about 0% to about 80% Hypromellose 2910 by weight, from about 0% to about 70% lactose by weight, from about 0% to about 70% microcrystalline cellulose by weight, and from about 0.1% to about 5% magnesium stearate by weight.
A method of manufacturing a composition, said method comprising the steps:
A method of manufacturing a composition, said method comprising the steps:
Dependencies are inferred from the claim text.