Manufacture of peanut formulations for oral desensitization
AssigneeAllergen Research Corporation
InventorsBryan Walser, Howard V. Raff
Life of this patent
Estimating the term…
Abstract
The present application relates to a method for managing the development and manufacturing process of a therapeutically effective formulation. Peanut proteins are characterized from peanut flour and encapsulated formulations made using the peanut flour for oral immunotherapy of peanut allergies.
Claims44
A method of making a low dose capsule formulation of peanut flour comprising characterized peanut proteins, comprising:
- (a) mixing peanut flour comprising characterized Ara h1, Ara h2 and Ara h6 and diluent in a first blend;
- (b) adding about 45% of diluent in a second blend;
- (c) adding remaining diluent in a third blend;
- (d) adding a glidant and/or lubricant in a final blend;
- and
- (e) encapsulating blended powder in a capsule.
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
A method of making a capsule formulation, comprising,
- (a) mixing peanut flour comprising characterized Ara h1, Ara h2 and Ara h6 and diluent in a first blend;
- (b) discharging the blended material;
- (c) passing the blended material through a mesh screen and blending the screened material in a second blend;
- (d) adding in a glidant and/or lubricant in a third blend;
- and
- (e) encapsulating the blended powder.
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
A method of making a capsule formulation, comprising,
- (a) mixing peanut flour comprising characterized Ara h1, Ara h2 and Ara h6, diluent, glidant and/or lubricant;
- (b) discharging the blended material;
- (c) passing the blended material through a mesh screen;
- and
- (d) encapsulating the blended powder.
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
Dependencies are inferred from the claim text.