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US 2014/0271832 A1Published application
Racecadotril lipid compositions
AssigneeMcNeil-PPC, Inc.
InventorDer-Yang Lee
Life of this patent
Estimating the term…
Abstract
A composition comprising racecadotril, at least one surfactant and a lipid.
Claims21
A composition comprising:
- racecadotril, at least one surfactant and a lipid,
- wherein the at least one surfactant is selected from the group consisting of a Tween, Dimethylacetamide (DMA), Dimethyl sulfoxide (DMSO), Ethanol, Glycerin, N-methyl-2-pyrrolidone (NMP), PEG 300, PEG 400, Poloxamer 407, Propylene glycol, Phospholipids, Hydrogenated soy phosphatidylcholine (HSPC), Distearoylphosphatidylglycerol (DSPG), L-α-dimyristoylphosphatidylcholine (DMPC), L-α-dimyristoylphosphatidylglycerol (DMPG), Polyoxyl 35 castor oil (CREMOPHOR EL, CREMOPHOR ELF), Polyoxyl 40 hydrogenated castor oil (Cremophor RH 40), Polyoxyl 60 hydrogenated castor oil (CREMOPHOR RH 60), Polysorbate 20 (TWEEN 20), Polysorbate 80 (TWEEN 80), d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS), Solutol HS-15, Sorbitan monooleate (SPAN 20), PEG 300 caprylic/capric glycerides (SOFTIGEN 767), PEG 400 caprylic/capric glycerides (LABRASOL), PEG 300 oleic glycerides (LABRAFIL M-1944CS), PEG 300 linoleic glycerides (LABRAFIL M-2125CS), Polyoxyl 35 Castor oil (ETOCAS 35), Glyceryl Caprylate (Mono- and Diglycerides) (IMWITOR), Polyoxyl 8 stearate (PEG 400 monosterate), Polyoxyl 40 stearate (PEG 1750 monosterate), polyoxyethylene derivative of sorbitan monolaurate such as polysorbate, caprylcaproyl macrogol glycerides, polyglycolyzed glycerides, and mixtures thereof,
- wherein the lipid is selected from the group consisting of vegetable oils (modified and/or hydrolyzed), long-chain triglycerides and medium-chain triglycerides having different degrees of saturation, monoglyceride, diglyceride, and/or triglyceride emulsifiers (fats and oils) that are lipophilic and insoluble in water, Beeswax, Oleic acid, Soy fatty acids, d-α-tocopherol (Vitamin E), Corn oil mono-di-tridiglycerides, Medium chain (C8/C10) mono- and diglycerides, Long-chain triglycerides, Corn oil, Cottonseed oil, Olive oil, Peanut oil, Peppermint oil, Safflower oil, Sesame oil, Soybean oil, Hydrogenated soybean oil, Hydrogenated vegetable oils, Medium-chain triglycerides, Caprylic/capric triglycerides derived from coconut oil, palm seed oil, and mixtures thereof.
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A composition comprising:
- about 0.1.0 wt. % to about 24.0 wt. % racecadotril;
- about 1 wt. % to about 95 wt. % of surfactant in total;
- and
- about 0.01 wt. % to about 20 wt. % lipid;
- wherein each wt. % is based upon 100 ml of the composition.
2 more elements
A composition comprising:
- about 3.0 wt. % to about 10.0 wt. % racecadotril;
- about 40 wt. % to about 53 wt. % of surfactant in total;
- and
- about 40 wt. % to about 53 wt. % lipid;
- wherein each wt. % is based upon 100 ml of the composition.
2 more elements
Dependencies are inferred from the claim text.