Pharmaceutical formulations of chelating agents as a metal removal treatment system
OwnerMark E. HAYES, Charles O. NOBLE +1inventors
InventorsMark E. HAYES, Charles O. NOBLE, Francis C. SZOKA, JR.
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Abstract
The present invention provides liposomes loaded with chelating agents, pharmaceutical formulations including these liposomes and methods of making chelating agent liposomes. Because the chelating agents are loaded in the liposome with high efficiencies, the liposomes are of use in treatment of metal ion overload in subjects. The liposomes can include two or more different chelating agents of different structures and affinities for metal ions.
Claims22
A liposome comprising an encapsulated chelating agent, said liposome having a chelating agent:lipid ratio of greater than about 220 grams of said chelating agent per mole of lipid comprising said liposome, said liposome having a diameter from about 20 nm to about 300 nm.
Dependencies are inferred from the claim text.