Onapristone polymorphic forms and methods of use
AssigneeArno Therapeutics, Inc.
InventorSTEFAN PRONIUK
Life of this patent
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Abstract
Polymorphic forms of onapristone and methods of making and using such polymorphic forms are provided. Crystalline polymorphic forms can be characterized by their X-ray powder diffraction patterns and other properties.
Claims20
An onapristone crystalline form characterized by the high resolution X-ray powder diffraction pattern of FIG. 4.
An onapristone crystalline form characterized by the X-ray powder diffraction pattern of FIG. 5.
An onapristone crystalline form characterized by the high resolution X-ray powder diffraction pattern of FIG. 9.
An onapristone crystalline form characterized by the X-ray powder diffraction pattern of FIG. 10.
An onapristone crystalline form characterized by the high resolution X-ray powder diffraction pattern of FIG. 14.
An onapristone crystalline form characterized by the X-ray powder diffraction pattern of FIG. 15.
An onapristone crystalline form characterized by the X-ray powder diffraction pattern of FIG. 16.
An onapristone crystalline form characterized by the X-ray powder diffraction pattern of FIG. 17.
The method of claim 16, the method of claim 43 where the mammal is a human.
A method of making an onapristone polymorphic form comprising combining onapristone with a solvent selected from the group consisting of water , methanol, ethanol, isopropanol, acetone, butanone, 2-, ethyl acetate, dioxane, 1,4-, tert-Butyl methyl ether, tetrahydrofuran, acetonitrile, chloroform, cyclohexane, n-heptane, toluene, xylene, p-, cumene, anisole, ethyl formate, and butyl acetate.
Dependencies are inferred from the claim text.