Methylphenidate transdermal compositions with rubber-based adhesives
AssigneeNoven Pharmaceuticals, Inc.
InventorJun Liao
Life of this patent
Estimating the term…
Abstract
Transdermal compositions comprising methylphenidate in a polymer matrix comprising a rubber-based pressure-sensitive adhesive are disclosed, such as a polymer matrix comprising styrene-isoprene-styrene or polyisobutylene polymers. Method of making such compositions, and therapeutic methods using them also are disclosed.
Claims18
A composition for the transdermal delivery of methylphenidate in the form of a flexible finite system for topical application, comprising a polymer matrix comprising:
- (a) about 10% to about 50% methylphenidate;
- (b) from about 30% to about 80% rubber-based polymer;
- (d) from about 10% to about 60% tackifying agent;
- (e) optionally, from about 0% to about 50% non-reactive acrylic polymer;
- (f) optionally, from about 0% to about 1% antioxidant;
- and
- (g) optionally, from about 0% to about 20% non-reactive excipient.
A method of manufacturing a composition for the transdermal delivery of methylphenidate in the form of a flexible finite system for topical application, comprising forming a polymer matrix comprising:
- (a) about 10% to about 50% methylphenidate;
- (b) from about 30% to about 80% rubber-based polymer;
- (d) from about 10% to about 60% tackifying agent;
- (e) optionally, from about 0% to about 50% non-reactive acrylic polymer;
- (f) optionally, from about 0% to about 1% antioxidant;
- and
- (g) optionally, from about 0% to about 20% non-reactive excipient.
Dependencies are inferred from the claim text.