Bioerodible Silicon-Based Delivery Vehicles for Delivery of Therapeutic Agents
AssigneepSivida US, Inc.
InventorsPaul Ashton, Gerard Riedel, Hong Guo
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Abstract
This invention discloses bioerodible delivery compositions for delivering peptide therapeutic agents. The delivery compositions comprise a porous silicon-based carrier material loaded with the therapeutic agent. The delivery compositions may be used in vitro or in vivo to deliver the therapeutic agent, preferably in a controlled fashion over an intended period of time such as over multiple days, weeks or months. The delivery compositions may be used for treating or preventing conditions of a patient such as chronic diseases.
Claims12
A sustained release drug delivery composition comprising:
- a) a porous carrier material comprising a silicon-based compound;
- and
- b) at least one therapeutic agent associated with the carrier material, wherein the at least one therapeutic agent includes adrenocorticotropic hormone (ACTH) or an analog thereof.
The delivery composition according to any preceding claim, wherein the silicon-based compound has a silica or silicon oxide surface.
The delivery composition according to any preceding claim, wherein the at least one therapeutic agent includes an ACTH analog selected from corticotropin, tetracosactide or cosyntropin.
The delivery composition according to any preceding claim, wherein the carrier material is sized for injection through a needle.
Dependencies are inferred from the claim text.