Novel type 1 diabetes vaccines, and methods of use
AssigneeUniversity of Florida Research Foundation, Inc.
InventorsJOSEPH LARKIN, MARK A. ATKINSON
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Abstract
The subject invention provides compositions for alleviating type 1 diabetes (T1D). In preferred embodiments, the compositions comprise an effective amount of one or more antigen presenting cells (APCs) that have been pulsed with one or more bacterial isolates and/or compounds from the isolates. The bacteria used to pulse the APCs are, preferably, those that confer upon the APCs the ability to inhibit the generation of diabetes-promoting T cells. In specific embodiments, these bacteria may be, for example, Eubacteria or Clostridia. In a preferred embodiment, the APCs are dendritic cells (DCs).
Claims18
A composition for treating or preventing type 1 Diabetes (T1D), the composition comprising an antigen presenting cell (APC) pulsed with a bacterium or a component of the bacterium, wherein the bacterium or the component of the bacterium confers upon the APC the ability to inhibit the generation of diabetes promoting T cells.
A method of treating or preventing T1D, the method comprising administering to a subject having T1D or having an increased risk of developing T1D, a composition comprising an effective amount of an APC pulsed with a bacterium or a component of the bacterium, wherein the bacterium or the component of the bacterium confers upon the APC the ability to inhibit the generation of diabetes promoting T cells in the subject.
A method of preparing a vaccine to treat or prevent T1D, the method comprising pulsing an APC with a bacterium or a component of the bacterium, wherein the bacterium or the component of the bacterium confers upon the APC the ability to inhibit the generation of diabetes promoting T cells.
Dependencies are inferred from the claim text.