Compositions and methods for treating clostridium difficile-associated diseases
AssigneeNational Health Research Institutes
InventorsPele Choi-Sing Chong, Jui-Hsin Huang, Chih-Hsiang Leng
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Abstract
Described herein are isolated polypeptides each containing one or more receptor-binding sites of toxin A (tcdA) of Clostridium difficile (Cd), nucleic acids encoding the polypeptides, and methods of using the polypeptides and nucleic acids.
Claims18
An isolated polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:2, 4, 6, and 8-18.
A kit for diagnosing Clostridium difficile infection or a disease associated with the infection, comprising one or more antibodies that each specifically bind to a polypeptide consisting of any of the sequences of SEQ ID NOs:2, 4, 6, and 8-18.
Dependencies are inferred from the claim text.