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US 2014/0271694 A1Published application
Antigen-specific methods of diagnosing and/or treating myocarditis or inflammatory cardiomyopathy
OwnerMyra A. Lipesinventor
Life of this patent
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Abstract
Provided herein are, for example, methods of diagnosing and/or treating inflammatory cardiomyopathy and/or post-myocardial injury autoimmunity. Such therapies involve suppressing an immune response to the alpha isoform of myosin heavy chain in the subject. In some embodiments, this suppression is done selectively.
Claims20
A method for treating post-myocardial injury autoimmunity in a subject, the method comprising:
- identifying an autoimmune-prone subject who has suffered a myocardial injury;
- and
- suppressing an immune response to the alpha isoform of myosin heavy chain (“alpha-myosin”) in the subject.
A method for treating post-myocardial injury autoimmunity, the method comprising:
- identifying a subject who has been infected or is at risk of being infected with a cardiotropic pathogen;
- and
- suppressing an immune response to the alpha isoform of myosin heavy chain (“alpha-myosin”) in the subject.
An alpha myosin-specific peptide comprising a contiguous stretch of at least 8 amino acids of SEQ ID NO:
- 1 and wherein the alpha myosin-specific peptide includes one or more of the following amino acids:
- 2, 4, 5, 8, 14, 33, 34, 35, 36, 37, 44, 52, 60, 65, 77, 103, 107, 110, 111, 135, 136, 197, 205, 209, 210, 211, 212, 213, 283, 304, 314, 319, 320, 327, 335, 348, 349, 350, 360, 367, 381, 417, 422, 424, 425, 435, 554, 562, 574, 586, 592, 596, 608, 618, 619, 623, 624, 627, 630, 631, 632, 633, 634, 636, 639, 640, 666, 680, 682, 730, 744, 790, 794, 797, 799, 801, 803, 806, 807, 811, 847, 853, 859, 861, 864, 901, 954, 1014, 1021, 1023, 1025, 1076, 1079, 1081, 1086, 1088, 1089, 1091, 1092, 1094, 1095, 1101, 1103, 1104, 1113, 1250, 1251, 1258, 1261, 1263, 1265, 1268, 1272, 1275, 1277, 1290, 1294, 1309, 1314, 1325, 1401, 1520, 1521, 1524, 1525, 1537, 1540, 1593, 1613, 1733, 1734, 1737, 1741, 1826, 1860, 1931, 1933, 1934, 1935, 1936, 1937, 1938, and 1939 of SEQ ID NO:
- 1, and wherein the peptide comprises a T cell immunodominant epitope.
Dependencies are inferred from the claim text.