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US 2014/0271687 A1Published application
Methods of Targeting T-Cells to Tumors
OwnerImre KOVESDI, Tibor BAKÁCS +1inventors
InventorsImre KOVESDI, Tibor BAKÁCS, Miklós SZABÓ
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Abstract
The invention provides a method of targeting T-cells to tumor cells using a tumor-associated antigen (TAA) specific antibody and a T-cell specific antibody, wherein the two antibodies can bind to each other through a high affinity avidin/biotin or streptavidin/biotin connection. The invention further provides methods to target activated T-cells to different tumor types by using a T-cell specific antibody that is specific to an activated T-cell surface molecule like CTLA-4.
Claims8
A method of targeting T-cells to tumor cells in a mammalian host, said method comprising:
- (a) administering to said mammalian host a first tumor specific antibody conjugated to a first member of a pair of specific binding moieties in an amount sufficient to bind to tumor cells in said mammalian host;
- (b) administering to said mammalian host a clearing compound conjugated to the second member of said pair of specific binding moieties and allowing sufficient amount of time for the non-tumor bound fraction of said conjugated first antibody to be eliminated from said mammalian host;
- (c) administering to said mammalian host a second T-cell specific antibody conjugated to the second member of said pair of specific binding moieties in an amount sufficient to bind to T-cells of said mammalian host;
- and
- (d) allowing sufficient amount of time for said first and second members of said pair of specific binding moieties to bind to each other, thereby targeting said T-cells to said tumor cells.
2 more elements
Dependencies are inferred from the claim text.