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US 2014/0271668 A1Published application
Increasing parkin activity by administering a deubiquitinating enzyme inhibitor
AssigneeGeorgetown University
InventorCharbel Moussa
Life of this patent
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Abstract
Provided herein are methods of promoting parkin activity in a subject, comprising: selecting a subject with a disorder associated with decreased Parkin activity; and administering to the subject an effective amount of a composition that increases parkin activity, wherein the composition is an inhibitor of a deubiquitinating enzyme.
Claims15
A method of promoting parkin activity in a subject, comprising:
- a) selecting a subject with a disorder associated with decreased Parkin activity;
- and
- b) administering to the subject an effective amount of a composition that increases parkin activity, wherein the composition is an inhibitor of a deubiquitinating enzyme.
A method of treating or preventing a neurodegenerative disease, a myodegenerative disease or prion disease in a subject, comprising:
- selecting a subject with a neurodegenerative disease of the central nervous system, a myodegenerative disease, a prion disease or at risk for a neurodegenerative disease of the central nervous system, a myodegenerative disease or a prion disease;
- and
- administering to the subject an effective amount of a composition that increases parkin activity, wherein the composition is an inhibitor of a deubiquitinating enzyme.
A method of treating or preventing cancer in a subject, comprising:
- selecting a subject with cancer;
- and
- administering to the subject an effective amount of a composition that increases parkin activity, wherein the composition is an inhibitor of a deubiquitinating enzyme.
Dependencies are inferred from the claim text.