US 2014/0271656 A1 · OPTIMIZED ANTIGENS OF PNEUMOCYSTIS AND USE THEREOF

Abstract

Immunologically active agents are described, including isolated Pneumocystis A 12 protein or polypeptides; immunogenic conjugates containing Pneumocystis A 12 protein or polypeptide of the present invention; antibodies recognizing the Pneumocystis A 12 protein or polypeptide or the immunogenic conjugates of the present invention; and nucleic acid molecules that encode the Pneumocystis A 12 protein or polypeptide of the present invention, as well as DNA constructs, expression vectors, and host cells that contain the nucleic acid molecules. Disclosed uses of the antibodies, immunogenic conjugates, and DNA constructs include inducing passive or active immunity to treat or prevent pathogen infections, particularly by a Pneumocystis organism, in a subject.

Claims39

Dependent claims

An isolated Pneumocystis A12 protein selected from the group consisting of:

a protein comprising more than 230 amino acid residues, wherein the isolated A12 protein has an amino acid sequence that is at least 20% identical to SEQ ID NO:
1;
a protein or polypeptide comprising an amino acid sequence that is at least 20% identical to residues 17-457 of SEQ ID NO:
1;
and
a protein or polypeptide fragment comprising an amino acid sequence that is at least 30% identical to a 25 contiguous amino acid sequence of SEQ ID NO:2.

3 more elements

Dependencies are inferred from the claim text.

Optimized antigens of pneumocystis and use thereof

Life of this patent

Optimized antigens of pneumocystis and use thereof

Life of this patent

Abstract

Claims39