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AssigneeRegeneron Pharmaceuticals, Inc.
InventorsAnne Gurnett-Bander, David Perez-Caballero, Sumathi Sivapalasingam, Xunbao Duan, Douglas MacDonald
Estimating the term…
The present invention provides fully human antibodies that bind to respiratory syncytial virus F protein, compositions comprising the antibodies and methods of use. The antibodies of the invention are useful for preventing fusion of the virus with the cell membrane and preventing cell to cell spread of the virus, thereby providing a means of preventing the infection, or treating a patient suffering from the infection and ameliorating one or more symptoms or complications associated with the viral infection. The antibodies may also be useful for diagnosis of an infection by RSV.
An isolated antibody or an antigen-binding fragment thereof that specifically binds to Respiratory Syncytial Virus F protein (RSV-F), wherein the antibody has one or more of the following characteristics:
An isolated antibody or an antigen-binding fragment thereof that specifically binds to Respiratory Syncytial Virus F protein (RSV-F), wherein the antibody or the antigen-binding fragment thereof interacts with an amino acid sequence comprising amino acid residues ranging from about position 161 to about position 188 of SEQ ID NO:
An isolated human antibody or antigen-binding fragment thereof that binds specifically to RSV-F, wherein the antibody comprises three heavy chain CDRs (HCDR1, HCDR2 and HCDR3) contained within a heavy chain variable region (HCVR) amino acid sequence selected from the group consisting of SEQ ID NO:
An isolated human antibody or antigen-binding fragment that specifically binds RSV-F comprising:
An isolated antibody or antigen-binding fragment thereof that competes for specific binding to RSV-F with an antibody or antigen-binding fragment comprising heavy and light chain sequence pairs selected from the group consisting of SEQ ID NOs:
An isolated antibody or antigen-binding fragment thereof that binds the same epitope on RSV-F that is recognized by an antibody comprising heavy and light chain sequence pairs selected from the group consisting of SEQ ID NOs:
An immunogenic composition comprising an amino acid sequence ranging from about position 161 to about position 188 of SEQ ID NO:
An immunogenic composition comprising the amino acid sequence of SEQ ID NO:
Dependencies are inferred from the claim text.