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AssigneeThe Administrators of the Tulane Educational Fund
InventorsRobert Francis GARRY, Russell B. WILSON
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Immunogenic influenza hemagglutinin-derived peptide conjugates described herein induce a specific therapeutic antibody response against influenza virus. The immunogenic peptide conjugates comprise a segment from the fusion initiation region (FIR) domain of an influenza hemagglutinin protein conjugated to an immunogenic carrier protein, such as keyhole limpet hemocyanin (KLH), bovine serum albumin (BSA), an influenza hemagglutinin (HA) protein (i.e., full length HA), and the like. The immunogenic peptide conjugates described herein can be utilized to treat or prevent influenza infection and to prepare influenza-specific therapeutic antibodies that interfere with influenza virus-host cell membrane fusion. The peptide conjugates can be formulated in pharmaceutical compositions useful for broad spectrum treatment or prevention of influenza infections.
An immunogenic peptide conjugate comprising a hemagglutinin fusion initiation region (FIR) peptide or a variant thereof, conjugated to an immunogenic carrier protein by a linking group;
An immunogenic peptide conjugate comprising a hemagglutinin fusion initiation region (FIR) peptide having an amino acid sequence that consists of SEQ ID NO:
The peptide conjugate of claim 9 wherein the immunogenic carrier protein is selected from the group consisting of the outer membrane protein complex of Neiserria meningitidis (OMPC), tetanus toxoid protein, diphtheria toxin derivative CRM197, bovine serum albumin (BSA), cationized BSA, Concholepas concholepas hemocyanin (CCH), hepatitis B virus (HBV) surface antigen protein (HBsAg), HBV core antigen protein, keyhole limpet hemocyanin (KLH), a rotavirus capsid protein, bovine pappiloma virus (BPV) L1 protein, a human papilloma virus (HPV) L1 protein, ovalbumin, and a full-length influenza hemagglutinin protein.
Dependencies are inferred from the claim text.