Thrombospondin-1 polypeptides and methods of using same
AssigneesUniversity of Guelph, Beth Israel Deaconess Medical Center, Inc.
InventorsJohn W. LAWLER, Mark Duquette, James Petrik
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Abstract
The invention features thrombospondin-1 (TSP-1) polypeptides (e.g., 3TSR-Fc fusion proteins), nucleic acid molecules encoding the TSP-1 polypeptides, and compositions thereof. The invention also features methods of making and using the TSP-1 polypeptides of the invention (e.g., using 3TSR-Fc fusion proteins to treat a subject having a disorder associated with pathological angiogenesis, e.g., cancer, e.g., epithelial ovarian cancer (EOC)).
Claims20
A polypeptide comprising a thrombospondin-1 (TSP-1) domain, or portion thereof, and a fragment crystallizable (Fc) region.
A method of treating a subject having a disorder associated with pathological angiogenesis comprising administering a therapeutically effective amount of a composition, wherein said composition comprises a polypeptide comprising an amino acid sequence having at least 90% sequence identity to any one of SEQ ID NOs:
- 1-7 or a polynucleotide encoding said polypeptide.
Dependencies are inferred from the claim text.