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US 2014/0271640 A1Published application
FGF-10 Complexes
AssigneePermeon Biologics, Inc.
InventorsKatherine S. Bowdish, Erik M. Vogan, John F. Ross, Ann Dewitt
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Abstract
The present disclosure provides complexes comprising an FGF-10 portion and a heterologous protein or peptide, as well as methods of using such complexes.
Claims54
A complex comprising
- an FGF-10 portion comprising a domain of a full length, unprocessed, naturally occurring fibroblast growth factor receptor 10 (FGF-10) polypeptide having a net positive charge, surface positive charge, a molecular weight of at least 4 kDa, and a charge per molecular weight ratio greater than that of a corresponding full length, unprocessed, naturally occurring FGF-10 polypeptide, which domain is a variant having one, two, three, four, or five amino acid substitutions, deletions, or additions relative to the corresponding domain of the naturally occurring FGF-10 polypeptide and that retains cell penetrating activity and
- a cargo portion comprising a heterologous protein or peptide or a small organic molecule;
- wherein the complex does not include a full length, unprocessed, naturally occurring FGF-10 polypeptide.
A complex comprising the amino acid sequence set forth in SEQ ID NO:
- 4, in the presence or absence of the N-terminal tag.
Dependencies are inferred from the claim text.