Methods for treating bleeding disorders
AssigneeBayer HealthCare LLC
InventorDerek Sim
Life of this patent
Estimating the term…
Abstract
Disclosed are methods for treating bleeding disorders, such as hemophilia, in subjects in need thereof by administering an antibody that specifically binds CD73. The methods reduce production of adenosine, increase platelet activation and/or enhance the level of coagulation on the platelet surface to reduce and/or stop bleeding. In some embodiments, the methods can further include co-administering Factor VIII to treat the bleeding disorder.
Claims22
A method for treating a bleeding disorder in a subject in need thereof, the method comprising administering a therapeutically effective amount of an antibody or fragment thereof that specifically binds CD73.
-18. (canceled)
A method for reducing adenosine generation in a subject in need thereof, the method comprising administering a therapeutically effective amount of an antibody or fragment thereof that specifically binds CD73.
A method for increasing platelet activation in a subject in need thereof, the method comprising administering a therapeutically effective amount of an antibody or fragment thereof that specifically binds CD73.
-31. (canceled)
Dependencies are inferred from the claim text.