Modified hyaluronan and uses thereof in cancer treatment
AssigneeNational Cheng Kung University
InventorsNan-Shan Chang, Wan-Pei Su
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Abstract
Uses of depolymerized hyaluronan (e.g., prepared by sonicating high molecular weight hyaluronan such as naturally-occurring hyaluronan) or anti-Hyal-2 antibody in cancer treatment. Also described herein are methods for preparing depolymerized and crosslinked hyaluronan by sonication and the hyaluronan composition thus obtained.
Claims24
A method for suppressing cancer cell growth, comprising contacting cancer cells with a composition comprising depolymerized hyaluronan, wherein the depolymerized hyaluronan comprises inter-chain covalent crosslinks, and wherein at least about 90% of the depolymerized hyaluronan has a molecular weight ranging from about 100-500 kDa.
A method for treating cancer, comprising administering to a subject in need thereof an effective amount of a pharmaceutical composition, which comprises depolymerized hyaluronan and a pharmaceutically acceptable carrier, wherein the depolymerized hyaluronan comprises inter-chain covalent crosslinks, and wherein at least about 90% of the depolymerized hyaluronan has a molecular weight ranging from about 100-500 kDa.
A method for preparing depolymerized and crosslinked hyaluronan, comprising sonicating high molecular weight hyaluronan at about 20-80 kHz for about 3-6 hours.
A method for treating cancer, comprising administering to a subject in need thereof an effective amount of an antibody capable of binding to hyaluronidase-2 (Hyal-2).
Dependencies are inferred from the claim text.