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US 2014/0271613 A1Published application
Surgical Compositions
AssigneeCovidien LP
InventorsTimothy Sargeant, Saumya Banerjee
Life of this patent
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Abstract
The present disclosure relates to multi-component hydrogels. The hydrogels may include a natural component having nucleophilic functional groups as well as an electrophilic component. In embodiments, at least one of the components may be branched, having drugs, antibodies, enzymes, and the like incorporated therein, which may react with at least one of the other components of the hydrogel. Hydrogels of the present disclosure may be used to deliver bioactive agents and/or cells to a patient.
Claims20
A therapeutic hydrogel comprising:
- a first hydrogel precursor comprising a natural component selected from the group consisting of collagen, serum, gelatin, hyaluronic acid, and combinations thereof;
- a second hydrogel precursor comprising an electrophilic functional group selected from the group consisting of n-hydroxysuccinimides, succinimidyl succinates, succinimidyl propionates, sulfosuccinimides, isocyanates, thiocyanates, carbodiimides, benzotriazole carbonates, and combinations thereof;
- and
- cells for delivery to a patient,
- wherein the first hydrogel precursor and the second hydrogel precursor react to form the therapeutic hydrogel, and
- wherein the therapeutic hydrogel has an osmolarity from about 200 mOsm/L to about 400 mOsm/L.
3 more elements
A method comprising:
- contacting a first hydrogel precursor comprising a natural component with a first buffer;
- contacting a second hydrogel precursor comprising an electrophilic functional group with a second buffer;
- adding cells to the first hydrogel precursor, the second hydrogel precursor, or both;
- contacting the first hydrogel precursor and the second hydrogel precursor;
- and
- forming a therapeutic hydrogel from the first hydrogel precursor and the second hydrogel precursor,
- wherein the therapeutic hydrogel has an osmolarity from about 200 mOsm/L to about 400 mOsm/L.
4 more elements
Dependencies are inferred from the claim text.