Collagen and alginate-based formulations for hemostasis
AssigneeOrthovita, Inc.
InventorJames San Antonio
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Abstract
The present invention relates to composition(s) comprising collagen, calcium ions and alginate, wherein the composition polymerizes in situ when contacted with blood. The composition may further comprise an erythrocyte aggregation agent and/or a platelet activation agent. The composition may be formulated into two separate formulations. The first formulation comprises collagen in a calcium-containing solution and a second formulation comprises an aqueous alginate solution. The two formulations can be mixed prior to the contact with blood or mixed coincident with the contact with blood.
Claims24
A composition comprising collagen, calcium ions, and alginate, wherein the composition polymerizes in situ when contacted with blood.
A kit comprising a first container comprising collagen and calcium ions and a second container comprising alginate.
A method of making a hemostat composition comprising:
- mixing collagen, calcium ions and alginate to form a mixture;
- and
- delivering the mixture to a site.
Dependencies are inferred from the claim text.