In vivo temporal control of activatable matrix-degrading enzymes
AssigneeHalozyme, Inc.
InventorsGilbert Keller, Gregory I. Frost
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Abstract
Methods and combinations are provided for controlling the duration of action, in vivo, of matrix-degrading enzymes. The methods and combinations permit temporary in-vivo activation of matrix-degrading enzymes upon administration to the extra cellular matrix (or “ECM”). Matrix-degrading enzymes having a controlled duration of action can be used to treat ECM-mediated diseases or disorders characterized by increased deposition or accumulation of one or more ECM components.
Claims23
A method for treating cellulite, comprising administering to the subject a composition comprising a cathepsin L enzyme, wherein the pH of the composition containing the cathepsin L enzyme is acidic, whereby cathepsin L is active for a limited time after administration to the subject to thereby treat the cellulite.
Dependencies are inferred from the claim text.